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August 1992

Multiple Plaques of Morphea Developing in a Patient With Eosinophilic Fasciitis

Author Affiliations

Department of Dermatology; Department of Rheumatology University Hospital Leiden Rijnsburgerweg 10 2333 AA Leiden, the Netherlands

Arch Dermatol. 1992;128(8):1128-1129. doi:10.1001/archderm.1992.01680180124021

To the Editor.—  Eosinophilic fasciitis (EF) is characterized by sclerodermalike changes associated with peripheral blood eosinophilia, hypergammaglobulinemia, and an elevated erythrocyte sedimentation rate.1 Since the first description by Shulman in 1974,2 over 200 patients with EF have been described. Whether EF is a variant of scleroderma or a separate disease entity is still unclear.Multiple plaques of morphea developed in our patient 1 year after EF was diagnosed, which suggests a possible relationship between the two disorders.

Report of a Case.—  In January 1989, a 62-year-old white woman with a history of osteoarthritis was referred to the outpatient clinic of our department because of pain and stiffness in the skin of her lower extremities. She had not taken any drugs or L-tryptophan. On examination, the skin of her lower extremities was edematous and indurated. A full-thickness (down to underlying muscle) biopsy specimen from the upper leg revealed a