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August 1992

Serum Vitamin A Levels in Psoriasis: Results From the First National Health and Nutrition Examination Survey

Author Affiliations

Office of Prevention Epidemiology and Clinical Applications National Institute of Arthritis and Musculoskeletal and Skin Diseases Building 31 Room 4C13 National Institutes of Health Bethesda, MD 20892

Arch Dermatol. 1992;128(8):1130-1131. doi:10.1001/archderm.1992.01680180126023

To the Editor.—  Several studies of serum vitamin A levels in patients with psoriasis have produced conflicting results.1-3 The current study utilizes data from a population-based examination survey to test the hypothesis that people with active psoriasis have lower serum vitamin A levels than control subjects free of psoriasis.Materials and Methods.—The First National Health and Nutrition Examination Survey (NHANES-I), conducted from 1971 to 1974, consisted of a probability sample of the US population. Details regarding the dermatologic examination have been described by the National Center for Health Statistics (NHCS), Hyattsville, Md.4This study also uses the results of a serum vitamin A assay that was performed as part of the survey.5 The mean vitamin A levels of white subjects graded by NHANES' examiners as having active psoriasis were compared with control subjects by the two-sample t test within age strata selected to minimize possible confounding