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September 1992

Topical Cyclosporine in the Treatment of Vulvar Lichen Sclerosus: Clinical, Histologic, and Immunohistochemical Findings

Author Affiliations

Department of Dermatology; Department of Obstetrics and Gynecology; Department of Pathology; Department of Dermatology University of Florence via della Pergola 58 50121 Florence, Italy

Arch Dermatol. 1992;128(9):1279-1280. doi:10.1001/archderm.1992.01680190139029

To the Editor.—  The topical application of cyclosporine could avoid the systemic side effects of the drug, making possible its use for localized immunomediated dermatoses. The sitespecific immunologic effects of topical cyclosporine have been demonstrated in animal models1; good effects in the treatment of mucosal lichen planus with topical cyclosporine have been reported by some authors.2Vulvar lichen sclerosus (LS) is a chronic dermatosis affecting a considerable percentage of women applying to centers for vulvar disease. Patients complain of pruritus, dryness, and dyspareunia; sclerofibrotic evolution is common, with different degrees of severity affecting the labia minora and atrophy of the clitoris. Although the pathogenesis of this disease is not completely known, the involvement of the skin immune system (SIS) in vulvar lesions of LS has been recently hypothesized by means of in situ immunologic studies3 showing activated T cells in the dermis and a persistent increase of

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