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December 1992

The Significance of Linear IgM Deposits in the Basement Membrane Zone

Author Affiliations

Department of Dermatology Utrecht University Hospital Heidelberglaan 100 3584 CX Utrecht, the Netherlands

Department of Dermatology Groningen University Hospital Oostersingel 59 9713 EZ Groningen, the Netherlands

Arch Dermatol. 1992;128(12):1653. doi:10.1001/archderm.1992.04530010089021

To the Editer.  —We read the article by Cobb and coworkers1 in the March 1992 issue of the Archives with interest. This article concerned a patient with Waldenström macroglobulinemia, a pruritic papular eruption, and IgM-K deposits in the epidermal basement membrane zone (BMZ). In 1988, we published an article concerning 25 patients with linear IgM deposits in the epidermal BMZ.2 These deposits were found in- diseased and in clinically healthy skin and tended to persist throughout the years. In 2771 biopsy specimens examined by means of routine immunofluorescence, the frequency of this feature was 0.9% (in comparison, the frequency of bullous pemphigoid was 1.2%; linear IgA dermatosis, 0.01%). We could find no common denominator when reviewing the patients' serologic data and clinical picture. The range of clinical symptoms was as follows: pruritus/urticaria, nine cases; purpura, five cases; vesicles/bullae, four cases; nonspecific rash, three cases; and ulcers, two cases.

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