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April 1993

A Pilot Study of Iontophoretic Cisplatin Chemotherapy of Basal and Squamous Cell Carcinomas of the Skin

Author Affiliations

Medical College of Georgia, Augusta; Tokai (Japan) University; Medical College of Georgia

Arch Dermatol. 1993;129(4):425-427. doi:10.1001/archderm.1993.01680250033004

REPORT OF A CASE  A 91-year-old man presented with a 2.9X2.0-cm nodular basal cell carcinoma (BCC) on the right cheek (Figure, top). This lesion was not previously treated because the patient had refused surgery or radiation therapy. The patient was in poor health due to atherosclerotic cardiovascular disease, with a history of myocardial infarction in 1982 and congestive heart failure. Other medical problems included a large hiatal hernia. Despite his refusal of other forms of treatment, the patient consented to iontophoresis with cisplatin, since his BCC had become painful and he desired pain relief.

THERAPEUTIC CHALLENGE  Palliative or potentially curative treatment of skin cancers in patients burdened with other chronic illnesses needs to be effective within tolerable limits of discomfort for the patient. Providing such outpatient care while minimizing the disruption in a patient's life is a challenge.

SOLUTION  Iontophoresis with suitable antineoplastic agents is a potentially attractive method of