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April 1993

Acute Undifferentiated Myeloblastic Leukemia Revealed by Specific Hemorrhagic Bullous Lesions

Author Affiliations

Clinique des Maladies Cutanées; Institut de Recherches sur les Leucémies et les Maladies du Sang; Laboratoire d'Anatomie-Pathologique; Service Clinique des Maladies du Sang; Clinique des Maladies Cutanées Hôpital Saint-Louis 1 Ave Claude Vellefaux 75010 Paris, France

Arch Dermatol. 1993;129(4):512-513. doi:10.1001/archderm.1993.01680250128025

To the Editor.—  Specific bullous lesions have been described in the course of malignant hemopathies, particularly in patients with chronic lymphocytic leukemia. The pathophysiology of these lesions still remains unknown. However, such lesions have only been exceptionally reported during myeloid leukemias. We describe a young woman who presented with hemorrhagic bullous lesions specific for acute myeloblastic leukemia.

Report of a Case.—  In March 1991, a 29-year-old white woman, without a significant medical history, had numerous buccal ulcerations. Oral antibiotics were administered and no improvement was noted. A few weeks later, painful skin lesions appeared on her fingers, followed by the development of hematomas and recurrent epistaxis. The patient was admitted to our hospital for further evaluation. Clinical examination disclosed an impressive stomatitis with several large ulcerations on the tongue, lips, and oral mucosa. Four skin lesions were noted on the dorsal aspect of her hands and fingers. These lesions had