[Skip to Navigation]
June 1993

Multiple Papules and Plaques in a Patient With Ovarian Carcinoma

Author Affiliations

Henry Ford Hospital, Detroit, Mich

Arch Dermatol. 1993;129(6):775-776. doi:10.1001/archderm.1993.01680270115016

REPORT OF A CASE  A 68-year-old white woman with stage III ovarian carcinoma presented to the dermatology clinic with multiple enlarging skin lesions of 1 month's duration. The lesions began on the scalp and had spread to involve her face, trunk, and extremities. They were asymptomatic.Physical examination revealed numerous reddish-brown indurated papules and plaques on the face, scalp, trunk, and proximal extremities (Figs 1 and 2).An initial skin biopsy specimen was interpreted as a largecell lymphoma. Several months later, a second biopsy specimen showed a dense infiltrate composed of large pleomorphic cells with vesicular nuclei and scattered mitoses (Fig 3). Some of the cells had an eosinophilic cytoplasm (Fig 4). A myeloperoxidase stain was strongly positive (Fig 5). T- and B-cell markers were uniformly negative. A bone marrow biopsy was recommended, and the specimen confirmed the diagnosis.What is your diagnosis?

DIAGNOSIS:  Granulocytic sarcoma (GS) of the skin.