To the Editor.—
Mucous membranes and systemic manifestations of toxic epidermal necrolysis (TEN) (also known as Lyell's syndrome) include oropharyngeal, ocular, genital, pulmonary, and intestinal involvement.1,2 Hyperamylasemia was reported in only a few cases and its origin, ie, salivary and/or pancreatic, remained controversial.3,4 The purpose of this study was to investigate the incidence and the origin of hyperamylasemia in TEN.
Materials and Methods.—
We reviewed retrospectively cases from 1985 through 1990 that fulfilled the criteria of TEN.1 Sixty-four patients with at least two determinations of amylase were included in the study. Amylase was assayed using the colorimetric method (α-amylase, Merck-Clevenot, Chelles, France) (normal, 50 to 220 U/L). Patients with hyperamylasemia (at least twice normal) were age and sex matched with patients without hyperamylasemia. These two groups of patients with TEN were compared for involvement of body surface area and mucous membranes, biological parameters (glycemia, serum aminotransferases levels,
Chosidow O, Wady ZE, Devanlay M, Jaffray P, Revuz J, Roujeau J. Hyperamylasemia in Toxic Epidermal Necrolysis. Arch Dermatol. 1993;129(6):792–793. doi:10.1001/archderm.1993.01680270136027
Browse and subscribe to JAMA Network podcasts!
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: