REPORT OF A CASE
A 58-year-old man was referred to us because of a widespread papulosquamous eruption.His history included mild diabetes for 12 years for which he had been receiving glyburide (15 mg/d) and metformin (850 mg/d). Three years ago, he had a myocardial infarction and began receiving acetylsalicylic acid (325 mg/d) and dipyridamole (75 mg three times daily). Oral quinidine bisulfate in sustained-action tablets had been added to therapy 1 month before admission for the management of premature ventricular contractions.On examination, erythematous scaly plaques were noted on his trunk and extremities (Figure 1). A biopsy specimen of a plaque showed focal parakeratosis and absence of granular cells at these areas, elongation of the rete ridges and the papillae with dilated capillaries within them, and a perivascular infiltrate composed of lymphocytes in the dermis (Figure 2).What is your diagnosis?
Psoriasiform eruption induced by quinidine.
Since an adverse reaction to quinidine had been suspected, he was instructed to discontinue this therapy. The lesions
Brenner S, Cabili S, Wolf R. Widespread Erythematous Scaly Plaques in an Adult. Arch Dermatol. 1993;129(10):1333–1334. doi:10.1001/archderm.1993.01680310103020
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: