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November 1993

The Molecular Medicine Issues

Arch Dermatol. 1993;129(11):1398. doi:10.1001/archderm.1993.01680320032003

THIS IS the third consecutive year that the 11 American Medical Association scientific journals will simultaneously emphasize a common topic. This year's theme is molecular medicine. This topic was chosen to celebrate the 40th anniversary of the publication of the two seminal articles by Watson and Crick.1,2 In these two short articles, they outlined the structure, the proposed function, and the genetic implications of deoxyribonucleic acid (DNA). This work marked the beginning of the revolution in understanding the molecular mechanisms regulating cellular function and disease. These insights formed the basis for much current biomedical research and for the biotechnology industry. Molecular diagnostic techniques permit more precise characterization of many diseases. Recombinant DNA technology and gene therapy provide approaches to therapy that were only dreamt about years ago. The human genome project, projected to map all 100 000 genes by the year 2005, will add further to the incredible increase

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