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April 1994

Cutaneous Crystalline Deposits in Myeloma

Author Affiliations

From the St John's Institute of Dermatology, St Thomas' Hospital, London, England (Drs Jenkins, Calonje, Greaves, and Wilson-Jones); and Basingstoke (England) District General Hospital (Dr Fawcett).

Arch Dermatol. 1994;130(4):484-488. doi:10.1001/archderm.1994.01690040088014

Background:  Myeloma is a plasma cell malignancy that usually presents with systemic manifestations or symptoms related to bone involvement. We describe the first case of crystalline protein deposition in the skin as the initial manifestation of myeloma.

Observations:  Crystals were found mainly in the extracellular space in the dermis of both involved and uninvolved skin in the absence of plasma cell infiltration. Crystals were also found in conjunctival tissue and bone marrow.

Conclusions:  We have described a unique case of myeloma that presented as facial and eyelid swelling. There were crystalline deposits in the skin and conjunetivae, but mechanisms of crystal formation and the factors causing local deposition were not established. However, treatment of the underlying disorder leads to resolution of the cutaneous features of crystal deposition.(Arch Dermatol. 1994;130:484-488)

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