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April 1994

Michael Bigby, MD

Arch Dermatol. 1994;130(4):534. doi:10.1001/archderm.1994.01690040142032

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Molecular Biology of the Skin is a short book devoted to reviewing the essential topics about the molecular biology of the keratinocyte for the medical and scientific communi- ties. The book consists of nine chapters written by 21 contributors, many of whom are prominent in the field. Topics covered include the molecular biology of human and murine keratins, expression and processing of fillagrin, the cornified envelope, loricrin, the effect of retinoic acid on epidermal differentiation, papilloma virus and malignant transformation, transgenic mouse models for studying skin disease, and keratinocytes as a target for gene therapy.

The book is extremely successful in its stated goal of summarizing the knowledge of the molecular biology of epidermal differentiation in a timely and readable fashion. The book is complete and written well enough to satisfy both a dermatologist interested in understanding the biology of the epidermis and a molecular biologist seeking to find state-of-the-art

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