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June 1994

Low-Dose Recombinant Interferon Alfa-2a Treatment for Classic Kaposi's Sarcoma

Author Affiliations

Madrid, Spain

Servicio de Dermatología Universidad Alcalá de Henares Hospital Ramón y Cajal Ctera Colmenar Km 9.100 28034 Madrid, Spain

Arch Dermatol. 1994;130(6):799-800. doi:10.1001/archderm.1994.01690060137023

We read with interest the article by Tur et al1 in the October 1993 issue of the Archives. They obtained good response in four patients using low-dose interferon alfa. In 1992, we also used low-dose interferon alfa to treat three patients with classic Kaposi's sarcoma, none of whom obtained any response (Table).

Report of Cases.Case 1.  A 70-year-old man of Mediterranean origin had a 3-year history of brown plaques with a purplish hue on his feet, legs, thighs, arms, hands, and nose. All of the plaques had the histologic features of Kaposi's sarcoma. Pain and edema were present on both legs. He received local radiotherapy on both feet with little response. Interferon alfa-2a (Roferon-A) (9 million U/d) was administered intramuscularly during a 7-month period. Because of leukopenia, the dose was reduced to 9 million U/d for 3 days per week subcutaneously during a 3-month period. Flattening was observed

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