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July 1994

Recurrence of Pemphigus Vulgaris Associated With Interleukin 2 Therapy

Author Affiliations

From the Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md.

Arch Dermatol. 1994;130(7):890-893. doi:10.1001/archderm.1994.01690070084013

Background:  Immunotherapy with recombinant interleukin 2 may result in regression of metastatic cancer, particularly malignant melanoma and renal cell carcinoma.

Observations:  We describe a patient who received interleukin 2 immunotherapy for metastatic renal cell carcinoma. After his second course of treatment, he developed a recurrence of pemphigus vulgaris that had been in remission for 10 years.

Conclusions:  Interleukin 2 therapy may be associated with recurrence of an autoimmune disease, perhaps because of its ability to stimulate autoantibody production.(Arch Dermatol. 1994;130:890-893)

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