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September 1994

Treatment of Pyoderma Gangrenosum With 4% Cromolyn

Author Affiliations

USA; USA; USA; USA; Darnall Army Hospital, Fort Hood, Tex (Drs Anderson and Cardone); Tripler Army Medical Center, Honolulu, Hawaii (Drs Samlaska and Holtzmuller)

Arch Dermatol. 1994;130(9):1117-1120. doi:10.1001/archderm.1994.01690090039004


CASE 1  In April 1986, a 23-year-old white woman presented with a 4× 5-cm nonhealing ulcerative plaque involving her right thigh. Symptoms of amenorrhea, weight gain, and icterus subsequently developed. Initial laboratory studies were remarkable for the following values or results: antinuclear antibody titer, 1:640; anti—smooth-muscle antibody titer, negative; bilirubin, 58 μmol/L (normal, 3 to 22 μmol/L; aspartate aminotransferase, 294 U/L (normal, 7 to 56 U/L); alanine aminotransferase, 337 U/L (normal, 14 to 56 U/L); alkaline phosphatase, 460 U/L (normal, 38 to 126 U/L); total protein, 82 g/L (normal, 63 to 83 g/L); albumin, 24g/L (normal, 37 to 55 g/L); prothrombin time, 14.7 seconds; hematocrit, 0.41; and platelets, 107×109/L.A cutaneous wedge resection at the site of the thigh ulceration showed acute and chronic inflammation of the dermis and sinus tract as well as abscess formation. The findings were consistent with the diagnosis of pyoderma

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