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December 1994

Clearing of Melanoma In Situ With Intralesional Interferon Alfa in a Patient With Xeroderma Pigmentosum

Author Affiliations

National Cancer Institute, Bethesda, Md (Drs Chanco Turner, Stern, Roth, DiGiovanna, and Kraemer); National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Md (Dr Moshell); US Naval Medical Center, Bethesda, Md (Dr Corbett); and The Johns Hopkins Medical School, Baltimore, Md (Dr Horn)

Arch Dermatol. 1994;130(12):1491-1494. doi:10.1001/archderm.1994.01690120027003

REPORT OF A CASE  The patient (XP1Be)1 is a 47-year-old, healthy woman with xeroderma pigmentosum (XP), complementation group C, who, from age 2 years, has had more than 200 nonmelanoma skin cancers, predominantly basal cell cancers. She had 34 primary melanomas: six were found to be minimally invasive while the rest were melanomas in situ (MIS). At the time of evaluation, she had 10 biopsyproven MIS remaining. The other melanomas had been surgically excised previously.Examination revealed an alert, intelligent, cheerful, blind patient. Both orbits had been enucleated after infiltrating squamous cell carcinomas failed to respond to surgery and radiation therapy. On a background of pale, freckled, telangiectatic skin, she had seborrheic keratoses, nonspecific keratotic papules, angiomas, solar lentigos, and scars. Numerous 3- to 4-mm white-to-pink atrophic and hypertrophic scars from small excisions or desiccation and curettage of nonmelanoma skin cancers covered her body. There were also large, deep

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