In a recent article, Blauvelt and Turner1 described two children infected with the human immunodeficiency virus who had clinical and histopathologic findings consistent with the Gianotti-Crosti syndrome (GCS). Furthermore, they attempted to define GCS by combining the classic descriptions of papular acrodermatitis of childhood and papulovesicular acrolocated syndrome into seven features: (1) 2- to 4-mm papules that are skin colored to red (occasionally microvesicles) located symmetrically on the extremities, face, and buttocks; (2) onset in childhood; (3) usually asymptomatic, however, occasionally pruritic; (4) average duration of 3 weeks, with reported cases lasting up to 2 months; (5) no recurrence; (6) nonspecific histologic features that may include a superficial perivascular lymphohistiocytic infiltrate, lymphocytic vasculitis, or lichenoid infiltrate with basal cell vacuolization; and (7) an association with an underlying viral illness. There is no mention of the characteristic Koebner phenomenon (isomorphic response) that is often present, especially in the early
Stratte EG, Esterly NB. Human Immunodeficiency Virus and the Gianotti-Crosti Syndrome. Arch Dermatol. 1995;131(1):108–109. doi:10.1001/archderm.1995.01690130112027
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