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January 1995

Human Immunodeficiency Virus and the Gianotti-Crosti Syndrome

Arch Dermatol. 1995;131(1):108-109. doi:10.1001/archderm.1995.01690130112027

In a recent article, Blauvelt and Turner1 described two children infected with the human immunodeficiency virus who had clinical and histopathologic findings consistent with the Gianotti-Crosti syndrome (GCS). Furthermore, they attempted to define GCS by combining the classic descriptions of papular acrodermatitis of childhood and papulovesicular acrolocated syndrome into seven features: (1) 2- to 4-mm papules that are skin colored to red (occasionally microvesicles) located symmetrically on the extremities, face, and buttocks; (2) onset in childhood; (3) usually asymptomatic, however, occasionally pruritic; (4) average duration of 3 weeks, with reported cases lasting up to 2 months; (5) no recurrence; (6) nonspecific histologic features that may include a superficial perivascular lymphohistiocytic infiltrate, lymphocytic vasculitis, or lichenoid infiltrate with basal cell vacuolization; and (7) an association with an underlying viral illness. There is no mention of the characteristic Koebner phenomenon (isomorphic response) that is often present, especially in the early

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