[Skip to Navigation]
February 1995

Recurrent Leg Ulcerations as the Initial Clinical Manifestation of Klinefelter's Syndrome

Author Affiliations

Toronto, Ontario

Division of Dermatology Department of Medicine Sunnybrook Health Science Centre 2075 Bayview Ave Toronto, Ontario, Canada M4N 3M5


Arch Dermatol. 1995;131(2):230. doi:10.1001/archderm.1995.01690140116028

Leg ulcers secondary to venous stasis are relatively uncommon in young men. Even in the presence of obvious venous disease, recurrent ulceration may be associated with chromosomal abnormalities such as Klinefelter's syndrome. Dermatologists should be aware that the first clinical presentation of Klinefelter's syndrome may be leg ulceration.

Report of a Case.  A 37-year-old man was hospitalized three times for the treatment of leg ulcers that were present for 1 year on the left medial malleolus and the lateral side of the lower aspect of the right leg. He had a 6-year history of bilateral varicose veins but no history of deep vein thrombosis or pulmonary embolus.Previous treatments included pinch grafting, splitthickness grafts, benzoyl peroxide, Debrisan, Duoderm, Burow's compresses, Unna's boot, and Bactigras.His medical history included asthma and seasonal allergies. He first noted small genitalia at age 16, when he began to put on weight, especially at the