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April 1995

Generalized Linear Porokeratosis Treated With Etretinate

Author Affiliations

Department of Dermatology Yale—New Haven Hospital 333 Cedar St LCI 500 New Haven, CT 06510

New Haven

Arch Dermatol. 1995;131(4):496-497. doi:10.1001/archderm.1995.01690160126029

Linear porokeratosis, also referred to as zosteriform porokeratosis, is characterized clinically by linear and whorled verrucous plaques that appear at birth or in childhood. Like other lesions of porokeratosis, long-standing lesions of linear porokeratosis may transform into Bowen's disease and squamous cell carcinoma.1 Extensive cases of linear porokeratosis present a therapeutic challenge. We report a case of linear porokeratosis that is remarkable because of its extent and response to therapy.

Report of a Case.  A 36-year-old white man with widespread, linear, verrucous lesions present since birth was self-referred for treatment recommendations because the lesions on his feet were interfering with his recreational activities. In infancy, he was diagnosed as having ''nevus verrucous ichthyosis'' without histologic confirmation. Until 35 years of age his only treatment was topical vitamin A and D ointment used to control fissuring and hyperkeratosis.On examination of the anterior part of the trunk and all extremities,

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