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May 1995

Rational Therapy for Cutaneous T-Cell Lymphomas in the 1990s: Fact or Fancy?

Author Affiliations

University of Colorado Cancer Center 4200 E Ninth Ave Box B-188 Denver, CO 80262

Arch Dermatol. 1995;131(5):603-605. doi:10.1001/archderm.1995.01690170105017

MYCOSIS FUNGOIDES (MF) and the Sézary syndrome (SS) are low-grade non-Hodgkin's lymphomas of helper T-Cell derivation.1. The term cutaneous T-cell lymphoma (CTCL) is often applied to these two conditions alone, but CTCL is also used to refer to any T-cell lymphoma in the skin, including intermediate and high-grade lymphomas such as peripheral T-cell lymphoma and adult T-cell leukemia/ lymphoma. With the exception of a small minority of stage IA cases, the low-grade lymphomas MF and SS are not curable with conventional therapy.2-6 Thus, the goal of treatment is palliation. While nearly all patients with MF and SS have symptoms from their skin lesions, there are many effective means of treating the skin, including irradiation therapy (especially electron beam),2 topical chemotherapy (especially nitrogen mustard),3 and photochemotherapy with psoralen plus UV light (PUVA).4 Unfortunately, most patients will eventually either fail to respond to these topical modalities or

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