We read with interest the case of ''Recurrence of Pemphigus Vulgaris Associated With Interleukin-2 Therapy'' reported by Prussick et al1 in a recent issue of the ARCHIVES. Indeed, pemphigus vulgaris (PV) and various autoimmune disorders reported during interleukin-2 immunotherapy are diseases in which interleukin-2 might play a key role. Interestingly, these diseases are rare events during interleukin-2 immunotherapy, as discussed by Gaspari in his editorial.2 In our own series of 25 patients with metastatic melanoma,3 we observed mucocutaneous lesions in 15% of 78 cycles of interleukin-2 infusion. Nine biopsy specimens were studied and did not reveal histologic or direct immunofluorescence patterns of autoimmune bullous skin diseases.
Nevertheless, we took a step toward Gaspari's ''unanswered questions'' concerning vitiligo and interleukin-2 therapy. Indeed, we had the opportunity to observe four cases of vitiligo in patients treated with interleukin-2 alone for metastatic melanoma out of our previous series of 25
Wolkenstein P, Revuz J, Guillaume JC, Avril MF, Chosidow O. Autoimmune Disorders and Interleukin-2 Therapy: A Step Toward 'Unanswered Questions'. Arch Dermatol. 1995;131(5):615–616. doi:10.1001/archderm.1995.01690170119022
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