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June 1995

Combined Features of Pemphigus Foliaceus and Bullous Pemphigoid: Immunoblot and Immunoelectron Microscopic Studies

Author Affiliations

Department of Dermatology Keio University School of Medicine 35 Shinanomachi Shinjuku Tokyo 160, Japan

Arch Dermatol. 1995;131(6):732-734. doi:10.1001/archderm.1995.01690180112024

Pemphigus foliaceus (PF) and bullous pemphigoid (BP) are blistering skin diseases caused by autoantibodies against the keratinocyte cell surface or the basement membrane zone (BMZ) of the epidermis, respectively. These diseases rarely coexist, with only three such cases reported.1-3 However, none has been studied by immunoelectron microscopy. In only one case was immunoprecipitation used to confirm the coexistence at the molecular level.3 We report coexistent PF and BP, in which a reactivity of the autoantibodies was studied by both immunoblot and immunoelectron micro scopic examination.

Report of a Case.  A 63-year-old Japanese man visited us complaining of blisters and erosions that involved almost the entire body. He had noticed crusted erythema on his back and had been treated under a diagnosis of PF for 6 years until tense vesicles and blisters developed rapidly on the trunk and extremities 3 months before his presenttion. Physical examination showed erythema with

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