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July 1995

Association of Prurigo With Hepatitis C Virus Infection

Author Affiliations


Tokyo, Japan

Mie, Japan

Immunology Division Jichi Medical School Tochigi 329-04, Japan

Arch Dermatol. 1995;131(7):852-853. doi:10.1001/archderm.1995.01690190108029

Nine hundred seventy-eight consecutive patients attending dermatology clinics were tested for markers of hepatitis C virus (HCV) infection. We noted a higher prevalence of serologic evidence of HCV infection in patients with idiopathic prurigo (Table). The 978 patients (336 males and 642 females) attended dermatology clinics at Ibaraki (Japan) Central Hospital and the Jichi Medical School, Tochigi, Japan, during the period from July 1991 through March 1993. They all complained of dermatologic problems; none of them had visited physicians for hepatitis. Serum samples were tested for markers of HCV infection.

Subjects and Methods.  Prurigo was diagnosed in 28 patients; 25 had prurigo simplex and the remaining three had prurigo nodularis (Hyde). Serum samples from all patients were tested for antibodies to synthetic HCV core peptides (anti-CP9 and anti-CP10) by enzyme immunoassays.1 Eleven (39%) of 28 patients with prurigo were positive for evidence of HCV infection at a significantly higher

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