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July 1995

Cutaneous Chronic Graft-vs-Host Disease and Hepatitis C Virus

Author Affiliations


Department of Dermatology Henri Mondor Hospital 5 Ave du Maréchal de Lattre de Tassigny 94010 Cretéil, France

Arch Dermatol. 1995;131(7):853-855. doi:10.1001/archderm.1995.01690190109030

Chronic graft-vs-host disease (GVHD) is a significant problem in patients who undergo bone marrow transplantation (BMT). It shares common clinical and histologic characteristics with lichen planus. The association of hepatitis C virus (HCV)-induced chronic hepatitis and lichen planus has been reported recently.1 To evaluate the possible role of HCV in the pathogenesis of chronic GVHD, two studies were performed in the BMT unit of our institution.

Patients and Methods.Cohort Study.  One hundred twenty-six consecutive patients who underwent allogeneic BMT between January 1987 and December 1991, with more than 6 months of follow-up post-BMT, were analyzed retrospectively. The mean age was 31 years. Chronic GVHD was defined as previously.2 Serum samples were obtained before and after BMT (mean delay, 11 months; [range, 6 to 54 months]). Anti-HCV antibodies were sought by a second-generation enzyme-linked immunosorbent assay (ELISA 2.0, Ortho Diagnostic Systems, Raritan, NJ) and a second-generation recombinant immunoblot

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