Cutaneous side effects of pefloxacin, a quinolone antibiotic, occur in 1.3% of treated patients and include photosensitivity, rash, pruritus, and a few cases of itchy erythema on face and forearms.1 We report the first case of a blue-black pigmentation of the legs associated with pefloxacin therapy reminiscent of the well-described skin pigmentation associated with minocycline therapy.1-3
Report of a Case.
A 60-year-old woman was admitted in June 1993 for extensive lymphedema of both legs and areas of blue-black macular pigmentation of the extensor surface of the lower legs and the dorsa of the feet (Figure 1). Since 1961, she had multiple sclerosis that induced a comFigure 1. Blue-black skin pigmentation of the legs associated with pefloxacin therapy.Figure 2. Biopsy specimen of pigmented skin (Perls' stain, ×1000). These dense deposits of black pigments were positive for Prussian blue, indicating the presence of iron. plete paralysis and lymphedema
Cleach LL, Chosidow O, Peytavin G, et al. Blue-Black Pigmentation of the Legs Associated With Pefloxacin Therapy. Arch Dermatol. 1995;131(7):856–857. doi:10.1001/archderm.1995.01690190112032
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