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September 1995

Mycosis Fungoides Palmaris et Plantaris

Author Affiliations

From the Departments of Dermatology, Medical College of Pennsylvania and Hahnemann University, Philadelphia (Drs Resnik, Kantor, and Vonderheid); Departments of Dermatology, University of Pennsylvania, Philadelphia (Drs Lessin and Chooback), and the Philadelphia Veterans Administration Medical Center (Dr Lessin); and the Departments of Pathology, Beth Israel Hospital and Harvard Medical School, Boston, Mass (Dr Kadin), and Medical College of Pennsylvania and Hahnemann University (Dr Cooper).

Arch Dermatol. 1995;131(9):1052-1056. doi:10.1001/archderm.1995.01690210082013

Background:  Mycosis fungoides primarily localized to the palms and soles is rare and has been previously reported as cutaneous lymphoma in four patients or as Woringer-Kolopp disease in eight patients.

Observations:  Four patients were initially diagnosed and treated unsuccessfully for various palmoplantar dermatitides until histopathologic findings revealed mycosis fungoides. Each case exhibited a clonal rearrangement of T-cell receptor gamma genes and immunohistochemical studies consonant with mycosis fungoides. All patients had limited skin involvement without evidence of extracutaneous involvement.

Conclusions:  Mycosis fungoides palmaris et plantaris is an uncommon expression of mycosis fungoides that manifests primarily on the palms and soles and clinically may mimic various inflammatory palmoplantar dermatoses. A biopsy is recommended in the evaluation of recalcitrant palmoplantar dermatoses.(Arch Dermatol. 1995;131:1052-1056)

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