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September 1995

PUVA-Bath Photochemotherapy Resulting in Rapid Clearance of Lymphomatoid Papulosis in a Child

Author Affiliations

Department of Dermatology Ludwig-Maximilians-University Frauenlobstrasse 9-11 D-80337 Munich, Germany

Arch Dermatol. 1995;131(9):1094. doi:10.1001/archderm.1995.01690210126030

Lymphomatoid papulosis (LyP) is a recurrent papulonodular skin disease affecting the trunk and extremities.1,2 In some patients, LyP may resolve spontaneously. However, in some patients skin lesions persist and, in approximately 10% of patients, may even progress into malignant lymphoma. In rare cases, LyP may occur in young adults or children. These young patients pose a most difficult therapeutic challenge, as therapies applied to patients with LyP, such as systemic administration of steroids or oral psoralens plus UVA (PUVA)3 are given to children very reluctantly.

Report of a Case.  A 6-year-old boy presented in May 1994 with multiple, large, erythematous, partially ulcerated nodules and nodes involving the trunk and extremities. Histopathologic assessment revealed a dense infiltrate that extended deeply into the reticular dermis that consisted of numerous atypical bizarre-shaped cells of different size. Immunophenotypic analysis demonstrated the presence of CD30+ cells. There were no signs of systemic involvement,

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