IT has been known for over two decades that induction of malignant skin tumors in rodents by midrange UV radiation (UVB radiation, 280 to 320 nm) involves not only an oncogenic event within the epidermis but also specific immunologic changes that serve to prevent or inhibit a vigorous immune response against the incipient tumor by the host immune system.1 Ultraviolet B—induced tumors in mice are highly immunogenic and fail to grow when transplanted to syngeneic recipients.2-4 Indeed, the transplanted tumors are destroyed and immunologic memory against the transplanted tumor can be detected. This observation led to a series of studies aimed at understanding why these immunogenic tumors grow in the primary host.
UV RADIATION INDUCES SPECIFIC IMMUNOLOGIC CHANGES IN MICE
Experiments performed in the 1970s by Kripke2,3 and Roberts et al4 demonstrated that prolonged and repetitive exposure to UVB radiation results not only in the appearance
Granstein RD. Evidence That Sunscreens Prevent UV Radiation-Induced Immunosuppression in HumansSunscreens Have Their Day in the Sun. Arch Dermatol. 1995;131(10):1201–1204. doi:10.1001/archderm.1995.01690220109022
Customize your JAMA Network experience by selecting one or more topics from the list below.