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October 1995

PUVA-Bath Photochemotherapy of Lichen Planus

Author Affiliations

Department of Dermatology Ludwig-Maximilians-University Frauenlobstrasse 9-11 D-80337 Munich, Germany

Arch Dermatol. 1995;131(10):1210-1211. doi:10.1001/archderm.1995.01690220118028

Lichen planus (LP) is a common inflammatory skin disease, accounting for approximately 1% of all diagnoses seen in patients seeking dermatologic care. In some patients, therapy remains difficult, and systemic application of glucocorticosteroids, cyclosporine, systemic photochemotherapy with psoralen plus UV-A (PUVA), and acitretin have been used with limited success.1 To circumvent the problems of oral PUVA therapy, methoxsalen (8-methoxypsoralen) in a dilute bathwater solution may be applied to the skin before UV-A.2 A PUVA-bath photochemotherapy regimen has been shown to be an elegant alternative in the treatment of psoria- sis.2,3 We describe our first four patients with LP who received PUVA-bath photochemotherapy.

Patients and Methods.  Four patients (age range, 42 to 76 years) with histopathologically proven LP received PUVA-bath photochemotherapy (Table). All had a history of LP for 14 to 24 months and had received topical or systemic glucocorticosteroids, oral PUVA (one patient), and acitretin (one patient),