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November 1995

Is the Combination of Tetracycline and Nicotinamide Therapy Alone Effective in Pemphigus?

Author Affiliations

Department of Dermatology Akdeniz University Medical Faculty 07070 Antalya, Turkey


Arch Dermatol. 1995;131(11):1339-1340. doi:10.1001/archderm.1995.01690230121025

The combination of tetracycline and nicotinamide has been used with varying degrees of success in the treatment of bullous pemphigoid,1 dermatitis herpetiformis,2 and linear IgA bullous dermatosis.3,4 In addition, this combination has been reported to be effective for pemphigus.3 The primary advantage of tetracycline and nicotinamide therapy compared with the other classic forms is a lower toxicity and broader safety profile.1-3 The present study was undertaken to investigate whether the combination of tetracycline and nicotinamide alone is effective in the treatment of pemphigus.

Patients and Method.  Fifteen patients, 10 with pemphigus vulgaris (PV), one with pemphigus vegetans (PVeg), two with pemphigus foliaceus (PF), and two with pemphigus erythematosus (PE), were enrolled in the study.The diagnosis was based on clinical examination and histopathologic and direct immunofluorescence studies.The patients were administered 2 g of tetracycline and 1.5 g of nicotinamide per day during the 2-month treatment period.