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We appreciate the comments of McGregor et al, and offer two comments in reply. First, our patient was not tested for subclinical anogenital HPV-16 infection, although given the widespread nature of his infection we suspect that the anogenital area was not exempt. Second, on the basis of the single case that we reported and in the absence of additional investigations, we would not infer that a majority of PUVA-associated skin cancers involve HPV-16 or a closely related type. This case, however, does suggest that HPV may play an important role in PUVA-induced skin cancers and that further investigation is warranted.
Weinstock MA, Bogaars HA, Larson PL, Burmer GC. Psoralen Plus UV-A-Associated Skin Cancer: A Likely Role for Human Papillomavirus Type 16?-Reply. Arch Dermatol. 1996;132(1):90. doi:10.1001/archderm.1996.03890250104020
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