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January 1996

Helicobacter pylori Antibodies in Patients With Psoriasis

Arch Dermatol. 1996;132(1):95-96. doi:10.1001/archderm.1996.03890250109026

Recently, it has been suggested that the gastric organism, Helicobacter pylori, much like group A β-hemolytic Streptococcus, may be one of the organisms capable of triggering psoriasis.1 One study of 32 patients with psoriasis noted that 47% of these patients had antibodies directed against H pylori.2 The current investigation was planned to determine if antibodies to H pylori could be found in a significant number of patients with psoriasis without known gastrointestinal complaints.

Subjects and Methods.  Patients with clinically typical psoriasis seen during the period from 1992 through 1994 were invited to participate in the study. Patients taking antibiotics, antacids, or other medications for gastrointestinal problems were excluded. Informed consent was obtained in all cases, and the study was approved by the Investigational Review Board at Norwalk Hospital, Nor-walk, Conn. Serum specimens were obtained from 33 volunteers ranging in age from 22 to 72 years; 18 volunteers were

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