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April 1996

Mycosis Fungoides Palmaris et Plantaris

Author Affiliations

Department of Dermatology and Pathology Stanford University School of Medicine 300 Pasteur Dr H2110 Stanford, CA 94305

Arch Dermatol. 1996;132(4):468. doi:10.1001/archderm.1996.03890280134021

I read with interest the article by Resnick et al,1 in which the authors attempt to group cases of limited acral cutaneous T-cell lymphoma into a single entity entitled "mycosis fungoides palmaris et plantaris." While this is certainly an admirable goal, I must object to the inclusion of several of their cases under such a designation, including a case report we published.2

Mycosis fungoides is defined as a neoplastic proliferation of CD4+ T-helper cells by most groups studying cutaneous T-cell lymphomas.3-5 Our case was that of a cutaneous T-cell lymphoma limited to an extremity for longer than 30 years, which was characterized by CD8+, CD30+, CD4- lymphocytes. This is not an immunophenotype that would ordinarily be seen in mycosis fungoides. In addition, almost half of all reported cases of Woringer-Kolopp disease (pagetoid reticulosis) are CD8+, CD4- T-cell lymphomas. These cases are neoplasms derived from a different population of

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