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April 1996

Pulsed Carbon Dioxide Laser, Trichloroacetic Acid, Baker-Gordon Phenol, and Dermabrasion: A Comparative Clinical and Histologic Study of Cutaneous Resurfacing in a Porcine Model

Author Affiliations

Dermatology Associates of San Diego County Inc Genesee Avenue, Suite 480 La Jolla, CA 92037

Arch Dermatol. 1996;132(4):469-471. doi:10.1001/archderm.1996.03890280135023

Recent advancements in carbon dioxide laser technology have allowed the development of microsecond-domain pulses with a high pulse energy (up to 500 mJ), enabling precise and complete tissue vaporization while minimizing residual thermal damage and its potential adverse effects on wound healing.1 For appropriate clinical application, one should know the depth of vaporization and residual thermal damage after successive laser passes over the same area, the depth of vaporization and residual thermal damage caused by different pulse energies, and how these in turn compare with the depth of tissue removal afforded by currently used resurfacing modalities: dermabrasion, 35% trichloroacetic acid peel, and Baker-Gordon (50%) phenol peel. To evaluate these immediate tissue effects and postoperative wound healing for all of these modalities, a clinical and histologic animal study was performed.

Materials and Methods.  A grid that delineated 16 treatment sites measuring 3×3 cm was tattooed onto the paravertebral area of

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