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June 1996

Extensive Fixed Drug Eruption Induced by Oxazepam

Author Affiliations

Dermatology Clinic University Hospital Geneva 24 rue Micheli du Crest CH-1211 Geneva 14, Switzerland


Arch Dermatol. 1996;132(6):718. doi:10.1001/archderm.1996.03890300148033

Numerous drugs have been reported to produce fixed drug eruptions (FDE).1 These drugs were first described by Brocq in 1894 and include analgesic, anti-infectious, cardiovascular, gastrointestinal, neurologic, psychopharmaceutical, and antineoplastic drugs. Benzodiazepines, although widely prescribed throughout the world, account for only a small minority of published cases of FDE. 1 Oxazepam has been rarely associated with diffuse exanthems and urticaria but, to our knowledge, no previous case of FDE has been reported with this drug.

Report of a Case.  An 85-year-old woman was admitted in September 1995 with a diffuse macular, erythematous, pruriginous eruption that appeared 3 months earlier. The eruption was clinically typical of an FDE. The patient was treated with low-dose aspirin and digoxin for paroxysmal atrial fibrillation. A history of oxazepam intake for insomnia was also noted. Histologic examination of a biopsy specimen from the lesion showed numerous keratinocyte necroses and lymphocytic dermal infiltrates. Results of

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