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July 1996

Are Neutrophilic Dermatoses During Granulocytopenia Really Neutrophilic?

Author Affiliations

Department of Dermatology Edouard Herriot Hospital 69437 Lyon Cedex O3, France

Saint-Etienne, France


Arch Dermatol. 1996;132(7):832. doi:10.1001/archderm.1996.03890310120022

In a recent study, Aractingi et al1 reported on 8 cases of neutrophilic dermatoses occurring during granulocytopenia. Although the role of neutrophils seems to be important in these diseases, the pathogeny is not well known. The involvement of other cell lineages is probable. In their study, Aractingi et al showed that neutrophilic dermatoses occurring during granulocytopenia are more frequently found in patients with French-American-British acute myeloid leukemia subtypes 4 and 5 (AML4 and AML5), ie, myelomonocytic and monocytic leukemias. Aractingi et al hypothesized that the neutrophils in the dermal infiltrate derived from differentiated leukemic cells. Both AML4 and AML5 are mainly related to malignant proliferation of monocytoid cells.2

Several works are in favor of the prominent role of dermal dendrocytes in the physiopathogeny of Sweet syndrome and other neutrophilic dermatoses.3-5 Jordaan3 showed that neutrophilic dermatoses pass through lymphocytic, neutrophilic, and histiocytic stages. Neutrophils are not necessarily

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