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July 1996

Are Neutrophilic Dermatoses During Granulocytopenia Really Neutrophilic?-Reply

Author Affiliations

On behalf of all coauthors Unité de Dermatologie Hôpital Tenon 4 rue de la Chine 75020 Paris, France

Arch Dermatol. 1996;132(7):832-833. doi:10.1001/archderm.1996.03890310120023

We thank Misery et al for their comments regarding our article and the interesting hypothesis that is raised. They wonder if the patients with the neutrophilic dermatoses occurring during granulocytopenia, whom we described, did not have, in reality, an infiltration of dermal dendrocytes instead of polymorphonuclear neutrophils. This relies on the description of a patient presenting with the clinical features of Sweet syndrome, in which immunohistochemistry disclosed the presence of CD68+ XIIIa+ cells in the dermis.1 Of note, the morphology of the infiltrating cells in this article is not given in detail and in the absence of one of the major criteria for Sweet syndrome, the precise diagnosis remains uncertain.

In the series by Jordaan, as discussed by Misery et al, neutrophils were present in 52 of 54 cases and were the prominent cell type in at least 36 of 54 cases.2 In contrast, histiocytes were prominent in

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