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July 1996

Absence of Human T-Cell Lymphotropic Virus Genomic Determinants in Canine Mycosis Fungoides

Author Affiliations

Department of Dermatology Henry Ford Hospital 2799 W Grand Blvd Detroit, MI 48202

Cleveland, Ohio




Arch Dermatol. 1996;132(7):841-842. doi:10.1001/archderm.1996.03890310133029

Cutaneous T-cell lymphoma (CTCL) is usually characterized by erythematous scaling patches, plaques, and tumors that can have a varied clinical course ranging from an indolent disease lasting for many years to a rapidly progressive fatal disease with extensive visceral involvement.1 Recently, we have reported that canine CTCL mimics human CTCL ultrastructurally, genetically, and immunophenotypically,2,3 and we propose that canine CTCL can be used as a model for the study of CTCL in humans.3-5 Pancake et al6 have associated human mycosis fungoides (MF) and the adult T-cell lymphoma/leukemia syndrome with human T-cell lymphotropic virus type 1 (HTLV-1). There is also a report of reverse transcriptase activity in 1 dog with CTCL, suggesting a retroviral link.4 Herein we show that there is no detectable HTLV-1 or HTLV-2n DNA in a total of 10 cases of canine CTCL by either routine Southern blot analysis or by the polymerase

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