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August 1996

Papular-Purpuric 'Gloves and Socks' Syndrome

Author Affiliations

Institute of Dermatological Sciences University of Milan, IRCCS Via Pace, 9 20122 Milan, Italy


Arch Dermatol. 1996;132(8):975-977. doi:10.1001/archderm.1996.03890320125026

In 1990, Harms et al1 described a new clinical entity that they descriptively defined as "papular-purpuric 'gloves and socks' syndrome" (PPGSS). These authors, on the basis of a careful review of the literature, concluded that PPGSS had never been described. After the first 5 patients reported by Harms et al,1 another 20 cases were published.1-17 One of these patients was seen in June 1993 at our institute.13

The recent discovery of 2 other cases has prompted us to present the results of a clinical and immunovirological study.

Report of Cases. Case 1.  A 39-year-old man was admitted because of a rash that was accompanied by a headache and localized exclusively to the hands and feet. The history was negative for intake of drugs. The rash was characterized by edema on which erythematopapular-purpuric lesions had developed: they were round, a few millimeters in diameter, slightly raised and

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