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November 1996

Hepatitis C Virus Infection in Patients With Psoriasis

Author Affiliations

Gunma-Ken, Japan

Ibaraki-Ken, Japan

Tokyo, Japan

Immunology Division Jichi Medical School Minamikawachi-Machi Tochigi-Ken 329-04, Japan

Arch Dermatol. 1996;132(11):1391-1392. doi:10.1001/archderm.1996.03890350135030

Hepatitis C virus (HCV) is known to induce various skin manifestations, most likely by the formation of circulating immune complexes.1 Previously, we reported that HCV is closely associated with prurigo, which can be treated with interferon.2 In an attempt to see if HCV infection is associated with other dermatologic manifestations, patients attending a dermatology clinic for the care of psoriasis were tested for antibody to HCV and HCV RNA.

During January 1994 and March 1995, 27 consecutive patients with psoriasis (16 men and 11 women) visited the dermatology clinic of the Isesaki Municipal Hospital, Gunma-Ken, Japan. None of the patients had been referred from other hospitals. Antibody to HCV was detected by the second-generation enzyme immunoassay in 9 (33%) of the 27 patients with psoriasis and antibody to synthetic HCV core peptides3 in 12 (44%). The frequency of antibody to HCV in the patients with psoriasis

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