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November 1996

Rapid Decrease of Phototoxicity After PUVA Bath Therapy With 8-Methoxypsoralen

Author Affiliations

Department of Dermatology Heinrich-Heine-University Düsseldorf Moorenstr 5 40225 Duesseldorf, Germany

University of Bochum Bochum, Germany

Arch Dermatol. 1996;132(11):1394. doi:10.1001/archderm.1996.03890350138033

PUVA bath therapy has distinct advantages compared with systemic PUVA therapy, eg, lack of systemic side effects and better bioavailability of psoralen.1-6 However, one astonishing drawback of the PUVA bath procedure is the lack of study-generated guidelines for the realization of the procedure. Therefore, we conducted 2 studies to determine the optimal time for irradiation and for how long photosensitivity persists after the bath. The biological activity of 8-methoxypsoralen (8-MOP) was evaluated by determination of the minimal phototoxicity dose (MPD). In a previous study7 on PUVA bath phototoxicity, we demonstrate that irradiation immediately and 20 minutes after the bath induces a relatively uniform ).ototoxic response with low UV-A doses (0.5-1.0 J/cm2). Thereafter, a rapid increase of the MPD occurred, thus indicating a decrease of drug activity.7 The aim of the present study was to evaluate the photosensitivity up to 4 hours after PUVA bath.

Materials and Methods.  Six

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