Five cases of cutaneous carcinoma occurred during long-term hydroxyurea therapy. Herein the responsibility of this drug in the onset of the tumors will be discussed.
Report of Cases.
Five white patients with skin photo-type II or III, were living in France and had no history of cutaneous carcinoma before treatment (Table 1 and Table 2). The patients received hydroxyurea for 2 to 10 years (mean, 6½ years), with cumulative doses between 650 and 3600 g. The patients' mean age was 71 years. Cutaneous carcinomas are actually frequent in the eighth decade of life; nevertheless, we suspect hydroxyurea of having a cutaneous carcinogenic effect in these patients, although it is now impossible to prove this. Indeed, our attention was drawn because of the sudden onset of tumors over a few weeks in patient 1, the large number and size of tumors in patients 2 and 5, and the remarkable absence of
Claire Callot-Mellot, Christine Bodemer, Olivier Chosidow, Camille Frances, Zai Azgui, Bruno Varet, Yves de Prost. Cutaneous Carcinoma During Long-term Hydroxyurea Therapy: A Report of 5 Cases. Arch Dermatol. 1996;132(11):1395–1397. doi:10.1001/archderm.1996.03890350139035