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November 1996

Granulocyte Colony-Stimulating Factor Treatment of Cyclic Neutropenia With Recurrent Oral Aphthae

Author Affiliations

Department of Dermatology University of Graz Auenbruggerplatz 8 A-8036 Graz, Austria


Arch Dermatol. 1996;132(11):1399-1400. doi:10.1001/archderm.1996.03890350143038

Cyclic neutropenia is a rare hematologic disorder characterized by a periodic decrease in blood neutrophil counts, accompanied by recurrent episodes of oral aphthae, fever, malaise, and skin infections with a periodicity of approximately 21 days. In 1989, the first report of effective treatment of cyclic neutropenia with granulocyte colony-stimulating factor (G-CSF) was published by Hammond et al,1 and further reports describing other patients successfully treated followed.2 We describe a young girl with a history of recurrent episodes of painful oral aphthae and fever dating from early childhood, with recurrent aphthous stomatitis associated with cyclic neutropenia, treated successfully with G-CSF.

Report of a Case.  A 16-year-old girl had recurrent episodes of oral aphthae, gingivitis, malaise, and fever since she was 6 months old, which recurred every 3 weeks. Her mouth lesions varied in severity, but usually were extremely painful and took 4 to 5 days to run their course.

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