REPORT OF A CASE
A 7-year-old girl presented with a slowly growing unilateral verrucous lesion in the vulvoanal region (Figure 1 ). Intermittent reddening, itching, and oozing of the lesion was reported. Histologic examination was performed for suspected neurodermatitis. Treatment with tar preparations and locally applied corticosteroids was unsuccessful. Exacerbation of the inflammatory manifestations and gradual growth of the lesion were observed. Cultures were negative for bacteria and yeasts. The diagnosis had to be reevaluated and a biopsy specimen was obtained (Figure 2).What is your diagnosis?Unilateral Perianogenital Papulokeratotic Lesion
Inflammatory linear verrucous epidermal nevus (ILVEN).
A second biopsy specimen (Figure 2) revealed hyperkeratosis and parakeratosis without the presence of neutrophils, acanthosis, papillomatosis, very slight spongiosis, and lymphohistiocytic infiltration of the upper dermis. The psoriasiform picture together with the clinical picture supported the diagnosis of ILVEN.
Inflammatory linear verrucous epidermal nevus usually develops in childhood. It is characterized by slowly
Opršalová K, Filo V, Danilla T, Mayrhofer-Schmid D. Unilateral Perianogenital Papulokeratotic Lesion. Arch Dermatol. 1996;132(12):1511–1512. doi:10.1001/archderm.1996.03890360103020
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: