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December 1996

Erythema Elevatum Diutinum and Crohn Disease: A Common Pathogenic Role for Measles Virus?

Author Affiliations

The Royal Free Hospital Pond Street London NW3 2QG, England


Arch Dermatol. 1996;132(12):1523-1525. doi:10.1001/archderm.1996.03890360117031

Erythema elevatum diutinum (EED) is a rare skin disease characterized by indolent purple, red, or yellowish papules and nodules, usually occurring symmetrically on extensor surfaces around acral joints. Histological features include a leukocytoclastic vasculitis of the mid- and upper-dermal vessels with fibrinoid necrosis, a dense dermal neutrophilic infiltrate, and, in older lesions, fibrosis.1 The most frequently reported condition associated with EED is hypergammaglobulinemia, but it is also reported in association with recurrent infections, rheumatoid arthritis, systemic lupus erythematosus, human immunodeficiency virus infection, and ulcerative colitis.1 To our knowledge, EED has been reported in only 1 other case of Crohn disease (CD).2 We report a second case of EED occurring in association with CD and the presence of persistent measles virus particles in granulomas in both gastrointestinal and skin lesions.

Report of a Case.  A 25-year-old West Indian woman, born in the United Kingdom, presented in March

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