We read with interest the articles by Fitzpatrick et al1,2 in recent issues of the Archives. We recently evaluated the histopathologic features seen in the skin of a weanling pig at 30 to 60 minutes after laser débridement using 1, 2, and 3 passes of a pulsed carbon dioxide laser (Tru-Pulse, Tissue Technologies, Albuquerque, NM). In addition to routine hematoxylin-eosin staining, we used nitroblue— tetrazolium chloride (NBTC) staining, a vital tissue stain using a mitrochondrial oxidation-reduction that subsides immediately after lethal cell damage.3 We also used pulsed carbon dioxide laser débridement to potentiate wound healing in weanling pigs exposed to sulfur mustard (bis[2-chloroethyl] sulfide; HD). Exposure to HD produces cutaneous lesions that heal slowly.4 Even mild exposures to HD that do not produce clinical blisters or ulcers cause atrophy, loss of basal cell morphologic characteristics, and significant cytologic atypia in the epidermis, as well as loss of
Smith KJ, Graham JS, Hamilton TA, Hackley BE, Skelton HG, Hurst CG. Additonal Observations Using a Pulsed Carbon Dioxide Laser With a Fixed Pulse Duration. Arch Dermatol. 1997;133(1):105–107. doi:10.1001/archderm.1997.03890370117023
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