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January 1997

Absence of Human Herpesvirus 8 DNA Sequences in Patients With Immunosuppression-Associated Dermatofibromas

Author Affiliations

Cardinal Bernardin Cancer Center Skin Disease Research Laboratories, Room 301 Loyola University Medical Center Maywood IL 60153-5385

Arch Dermatol. 1997;133(1):108-109. doi:10.1001/archderm.1997.03890370120026

Using representational DNA analysis, previously unknown herpesviruslike DNA sequences (designated human herpesvirus 8 [HHV-8]) were discovered in Kaposi sarcoma (KS) lesions from patients with acquired immunodeficiency syndrome (AIDS).1 We recently summarized this rapidly advancing field dealing with HHV-8 and immunodeficiency-associated diseases, such as KS.2 Despite an earlier suggestion that HHV-8 DNA sequences were present in proliferating skin lesions other than KS in transplant recipients, other studies3-5 have found no evidence of HHV-8 DNA sequences in cutaneous epithelial neoplasms from either immunosuppressed or immunocompetent patients. To continue exploring the possible role of HHV-8 in other non-KS skin tumors, we examined multiple dermatofibromas in the clinical setting from patients with an autoimmune disease: systemic lupus erythematosus (SLE).

In contrast to the common occurrence of 1 to 2 dermatofibromas in otherwise healthy individuals, dozens and even hundreds of dermatofibromas can erupt on the skin of patients with altered immunological