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January 1997

Kaposi Sarcoma-Associated Herpesvirus/Human Herpesvirus Type 8 and Epstein-Barr Virus in latrogenic Kaposi Sarcoma

Author Affiliations


Case Western Reserve University and Veterans Affairs Medical Center 10701 East Blvd Cleveland, OH 44106

Arch Dermatol. 1997;133(1):109-111. doi:10.1001/archderm.1997.03890370121027

Kaposi sarcoma (KS) occurs in 4 distinct settings categorized as classic KS, African-endemic KS, epidemic (acquired immunodeficiency syndrome [AIDS]—related) KS, and iatrogenic (immunosuppressive drug—associated) KS.1 A new human herpesvirus, designated KS—associated herpesvirus (KSHV) or human herpesvirus type 8 (HHV-8), was first identified by Chang et al2 in tissue from patients with epidemic KS. Subsequent studies demonstrated KSHV in tissue from patients with the other 3 forms of KS.3,4 However, the reported cases of iatrogenic KS have all been in patients receiving organ transplants. Recently, KSHV has also been found in AIDS—related body cavity—based lymphomas, Castleman disease, and various cutaneous squamoproliferative lesions in patients receiving organ transplants.5-7 Interestingly, some cases of AIDS-related body cavity—based lymphomas were also shown to contain Epstein-Barr virus (EBV) DNA sequences. To our knowledge, the association of KSHV and EBV has not been reported previously in lesional KS tissue. We describe an

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