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February 1997

Treatment of Chronic Urticaria With Ketotifen

Author Affiliations

University of Utah Health Sciences Center, Salt Lake City

Arch Dermatol. 1997;133(2):147-149. doi:10.1001/archderm.1997.03890380015002

REPORT OF A CASE  A 43-year-old white woman presented with a 5-month history of urticaria and pruritus following an influenza vaccine injection and an episode of pneumonia in October 1993. The patient had seen numerous dermatologists and had been treated with oral prednisone (maximum dose, 180 mg/d) and oral antihistamines, which resulted in excessive drowsiness. The patient also reported episodes of breathing difficulty, which resulted in several emergency department visits. Additional medications included levothyroxine sodium, a combination of amiloride hydrochloride and hydrochlorothiazide, and fluoxetine hydrochloride. Discontinuing treatment with these medications for 3 months did not improve her urticaria. She then developed severe depression and was suicidal because of her unrelenting urticaria.The patient's medical history was significant for sarcoidosis involving her lungs 10 years previously, a goiter treated with radioactive iodine therapy, severe endometriosis requiring a total abdominal hysterectomy with a salpingo-oophorectomy, and rheumatic fever as a child.A physical