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May 1997

Chromoblastomycosis Produced by Aureobasidium pullulans in an Immunosuppressed Patient

Author Affiliations

Department of Dermatology University Clinic of Navarra PO Box 192 31080 Pamplona, Spain


Arch Dermatol. 1997;133(5):663-664. doi:10.1001/archderm.1997.03890410127025

Black fungi," or dematiaceous fungi, are characterized by the development of a brown to black color in their vegetative cells and/or conidia. This color is due to dihydroxynaphthalene. Chromoblastomycosis is a chronic cutaneous and subcutaneous infection of the skin caused by species of dematiaceous fungi. Chromoblastomycosis or pseudocarcinomatous cutaneous infections caused by species of Aureobasidium have not previously been reported, to our knowledge. We describe a liver transplant recipient who developed a cutaneous infection by Aureobasidium pullulans following treatment with tacrolimus.

Report of a Case.  A 55-year-old man with cirrhosis caused by the hepatitis C virus received a liver transplant in January 1994. After the procedure the patient was treated with cyclosporine, azathioprine, and methylprednisolone acetate. Between February and June 1994 the patient received 6 boluses of 1 g of methylprednisolone acetate for 2 acute rejection episodes. In December 1994 he developed chronic rejection and rescue treatment was started with